Investigating the role of N-acetyltransferase 8-like (NAT8L) in whole body energy metabolism and the consequences for the heart Summary
نویسنده
چکیده
Background: Imbalances in cellular energy homeostasis can lead to diseases such as type 2 diabetes, cardiovascular disease and cancer. The heart, which has to contract incessantly, is very sensitive to nutritional changes and requires optimal energy to fuel adjustment [1]. N-acetylaspartate (NAA) is one of the most abundant metabolites in brain [2] with yet unknown function. NAA is synthesized by mitochondrial N-acetyltransferase 8-like (NAT8L) and catabolized by cytoplasmic aspartoacylase (ASPA), building the so called NAA pathway [3–7]. Several studies linked NAA to neuronal osmoregulation, lipid synthesis and energy metabolism [8, 9]. We were the first to show that the NAA pathway functionally exists in (brown) adipose tissue [5]. Further, we demonstrated that manipulation of the NAA pathway impacts brown adipocyte lipid turnover (lipogenesis and lipolysis), brown marker gene expression, and cellular respiration in vitro [5] and in vivo, thereby impacting whole body energy metabolism (unpublished).
منابع مشابه
Investigating the role of N-acetyltransferase 8-like (NAT8L) in whole body energy metabolism and the consequences for the heart
Background: Imbalances in cellular energy homeostasis can lead to diseases such as type 2 diabetes, cardiovascular disease and cancer. The heart, which has to contract incessantly, is very sensitive to nutritional changes and requires optimal energy to fuel adjustment [1]. N-acetylaspartate (NAA) is one of the most abundant metabolites in brain [2] with yet unknown function. NAA is synthesized ...
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